<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:13f38581-8238-4bc7-98d7-fc1e884a60b3,g:2d139f62-f1db-4645-8ce2-54b824e10de1-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://cassinfo.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="cass-20220331.xsd#CONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_56a0be6d-17f8-4c70-a0bd-e0b1824d2fcf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_821c2bf6-4a4c-4ff8-a643-aa1751cd5c25" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Deposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_56a0be6d-17f8-4c70-a0bd-e0b1824d2fcf" xlink:to="loc_us-gaap_Deposits_821c2bf6-4a4c-4ff8-a643-aa1751cd5c25" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cass_AccountsAndDraftsPayable_42ea8296-36a4-4af2-803c-1baa1cba94b4" xlink:href="cass-20220331.xsd#cass_AccountsAndDraftsPayable"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_56a0be6d-17f8-4c70-a0bd-e0b1824d2fcf" xlink:to="loc_cass_AccountsAndDraftsPayable_42ea8296-36a4-4af2-803c-1baa1cba94b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilities_f6ec1854-7b3b-4e67-abd1-249560018482" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_56a0be6d-17f8-4c70-a0bd-e0b1824d2fcf" xlink:to="loc_us-gaap_OtherLiabilities_f6ec1854-7b3b-4e67-abd1-249560018482" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_3728dbd4-eb5b-4ad4-b542-c79b7c0087dc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_3d9fa3d1-0180-49ac-a234-f51ba288beaa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_3728dbd4-eb5b-4ad4-b542-c79b7c0087dc" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_3d9fa3d1-0180-49ac-a234-f51ba288beaa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest_8d89b566-95ea-4bfd-9179-2113b41a86e9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_3728dbd4-eb5b-4ad4-b542-c79b7c0087dc" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest_8d89b566-95ea-4bfd-9179-2113b41a86e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_7b8bf248-264e-48cb-b9e6-bb0871af0788" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Deposits"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestBearingDepositLiabilities_de412678-b81f-4ae6-8858-7c5ff459e994" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestBearingDepositLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_7b8bf248-264e-48cb-b9e6-bb0871af0788" xlink:to="loc_us-gaap_NoninterestBearingDepositLiabilities_de412678-b81f-4ae6-8858-7c5ff459e994" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestBearingDepositLiabilities_03468927-d30a-4627-a48d-b6507f621030" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestBearingDepositLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_7b8bf248-264e-48cb-b9e6-bb0871af0788" xlink:to="loc_us-gaap_InterestBearingDepositLiabilities_03468927-d30a-4627-a48d-b6507f621030" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_a677b268-3a77-490e-8ff8-49e3514e783e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_90ed4989-583f-4a9e-8346-7c1bd4c532d6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsAndShortTermInvestments"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a677b268-3a77-490e-8ff8-49e3514e783e" xlink:to="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_90ed4989-583f-4a9e-8346-7c1bd4c532d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_e9d304aa-b4bb-4bb6-9236-3a3cdb51ea6b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a677b268-3a77-490e-8ff8-49e3514e783e" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_e9d304aa-b4bb-4bb6-9236-3a3cdb51ea6b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_c7e94163-e613-43ef-9bff-01ba9c1eba2d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a677b268-3a77-490e-8ff8-49e3514e783e" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_c7e94163-e613-43ef-9bff-01ba9c1eba2d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_cd7287a9-b961-4d92-92d0-88d09e1c6bf7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a677b268-3a77-490e-8ff8-49e3514e783e" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_cd7287a9-b961-4d92-92d0-88d09e1c6bf7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankOwnedLifeInsurance_90bc3d09-8455-4804-a3af-7d11d9482805" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BankOwnedLifeInsurance"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a677b268-3a77-490e-8ff8-49e3514e783e" xlink:to="loc_us-gaap_BankOwnedLifeInsurance_90bc3d09-8455-4804-a3af-7d11d9482805" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cass_PaymentsInAdvanceOfFunding_25dc2848-ffe7-4456-b2ce-f195552c4732" xlink:href="cass-20220331.xsd#cass_PaymentsInAdvanceOfFunding"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a677b268-3a77-490e-8ff8-49e3514e783e" xlink:to="loc_cass_PaymentsInAdvanceOfFunding_25dc2848-ffe7-4456-b2ce-f195552c4732" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_4eea2ded-1ae5-42c5-b92c-b8546d769ffb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a677b268-3a77-490e-8ff8-49e3514e783e" xlink:to="loc_us-gaap_Goodwill_4eea2ded-1ae5-42c5-b92c-b8546d769ffb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_7cae5a28-08ca-4e8d-b710-dda461a53818" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a677b268-3a77-490e-8ff8-49e3514e783e" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_7cae5a28-08ca-4e8d-b710-dda461a53818" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssets_c83d3841-5aec-4325-ba5c-a1c8e060e0b8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssets"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_a677b268-3a77-490e-8ff8-49e3514e783e" xlink:to="loc_us-gaap_OtherAssets_c83d3841-5aec-4325-ba5c-a1c8e060e0b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_0f361cff-a4b6-4e3f-8f92-7a4e00798cec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_0a6f75dc-3fb4-489e-abf1-245c1c7e9af5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_0f361cff-a4b6-4e3f-8f92-7a4e00798cec" xlink:to="loc_us-gaap_Liabilities_0a6f75dc-3fb4-489e-abf1-245c1c7e9af5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_1ae871bb-47f9-4155-bf63-6cba6a3342d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_0f361cff-a4b6-4e3f-8f92-7a4e00798cec" xlink:to="loc_us-gaap_StockholdersEquity_1ae871bb-47f9-4155-bf63-6cba6a3342d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_5786d2d5-1610-40ab-be2c-3f43ad00a20d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsAndShortTermInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndDueFromBanks_254a9c84-a08c-4fe3-8b4b-3dfcf4a4c91a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndDueFromBanks"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_5786d2d5-1610-40ab-be2c-3f43ad00a20d" xlink:to="loc_us-gaap_CashAndDueFromBanks_254a9c84-a08c-4fe3-8b4b-3dfcf4a4c91a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_b2c15fb2-aebc-41a9-b7ed-ec7b69e518fa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_5786d2d5-1610-40ab-be2c-3f43ad00a20d" xlink:to="loc_us-gaap_ShortTermInvestments_b2c15fb2-aebc-41a9-b7ed-ec7b69e518fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_8e49150f-ce8e-4ec4-84d1-462770e2e02e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_d58bf6a6-904e-4cc8-8046-3c15f6fcfcb3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8e49150f-ce8e-4ec4-84d1-462770e2e02e" xlink:to="loc_us-gaap_PreferredStockValue_d58bf6a6-904e-4cc8-8046-3c15f6fcfcb3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_f9e20311-b87b-41f3-9d7b-1072e79a5147" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8e49150f-ce8e-4ec4-84d1-462770e2e02e" xlink:to="loc_us-gaap_CommonStockValue_f9e20311-b87b-41f3-9d7b-1072e79a5147" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_0435feae-09a2-4633-8b0b-2ae2e9dd18f9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8e49150f-ce8e-4ec4-84d1-462770e2e02e" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_0435feae-09a2-4633-8b0b-2ae2e9dd18f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_3ea6acfa-3964-4986-abb8-412097fe7233" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8e49150f-ce8e-4ec4-84d1-462770e2e02e" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_3ea6acfa-3964-4986-abb8-412097fe7233" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_e192e914-5d31-4c5d-bdb2-04f2e3fabb1f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8e49150f-ce8e-4ec4-84d1-462770e2e02e" xlink:to="loc_us-gaap_TreasuryStockValue_e192e914-5d31-4c5d-bdb2-04f2e3fabb1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_6e848046-10e9-45ed-910d-36f25ff0762a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8e49150f-ce8e-4ec4-84d1-462770e2e02e" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_6e848046-10e9-45ed-910d-36f25ff0762a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/CONSOLIDATEDSTATEMENTSOFINCOME" xlink:type="simple" xlink:href="cass-20220331.xsd#CONSOLIDATEDSTATEMENTSOFINCOME"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/CONSOLIDATEDSTATEMENTSOFINCOME" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_f384f0eb-e4e4-47ac-a962-4d1b0df8314d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_e2de7b45-e724-489c-885e-8b466cd3afc4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_f384f0eb-e4e4-47ac-a962-4d1b0df8314d" xlink:to="loc_us-gaap_Revenues_e2de7b45-e724-489c-885e-8b466cd3afc4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_3b3d3efd-cce5-48bb-aae0-b52cb5a60293" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_f384f0eb-e4e4-47ac-a962-4d1b0df8314d" xlink:to="loc_us-gaap_NoninterestExpense_3b3d3efd-cce5-48bb-aae0-b52cb5a60293" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_14ca18fd-d143-4707-86f2-0eadea7b24b1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e9f8f3cf-f43f-47de-aaa4-eda01a533c64" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_14ca18fd-d143-4707-86f2-0eadea7b24b1" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e9f8f3cf-f43f-47de-aaa4-eda01a533c64" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_bb0cbf9c-0ea9-4acf-8f79-06d43c9b6200" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_14ca18fd-d143-4707-86f2-0eadea7b24b1" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_bb0cbf9c-0ea9-4acf-8f79-06d43c9b6200" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_583dcb0e-d01f-467f-bf05-988420abebbe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_dc27c3bc-b097-4cc8-84ff-efa9d2689cd8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_583dcb0e-d01f-467f-bf05-988420abebbe" xlink:to="loc_us-gaap_InterestIncomeExpenseNet_dc27c3bc-b097-4cc8-84ff-efa9d2689cd8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanLossesExpensed_dfffff87-a826-428c-843b-affdbe0f14ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProvisionForLoanLossesExpensed"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_583dcb0e-d01f-467f-bf05-988420abebbe" xlink:to="loc_us-gaap_ProvisionForLoanLossesExpensed_dfffff87-a826-428c-843b-affdbe0f14ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_f9af6257-2f6c-41f6-a53c-3a963c0729cf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_636ac92e-677a-444d-9590-a37ac1814d29" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_f9af6257-2f6c-41f6-a53c-3a963c0729cf" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_636ac92e-677a-444d-9590-a37ac1814d29" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueNotFromContractWithCustomerOther_4ff2f55e-b4da-4f19-a75f-1c806f587d9a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueNotFromContractWithCustomerOther"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_f9af6257-2f6c-41f6-a53c-3a963c0729cf" xlink:to="loc_us-gaap_RevenueNotFromContractWithCustomerOther_4ff2f55e-b4da-4f19-a75f-1c806f587d9a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_9efecc3f-6452-46d2-a2c9-9db7b2bba188" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_18ea494b-00f4-4d62-902a-2af7e6f701bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9efecc3f-6452-46d2-a2c9-9db7b2bba188" xlink:to="loc_us-gaap_LaborAndRelatedExpense_18ea494b-00f4-4d62-902a-2af7e6f701bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OccupancyNet_235e63c5-281b-4ed1-96f0-f88a35cd1611" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OccupancyNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9efecc3f-6452-46d2-a2c9-9db7b2bba188" xlink:to="loc_us-gaap_OccupancyNet_235e63c5-281b-4ed1-96f0-f88a35cd1611" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquipmentExpense_c4b85f0a-b54f-4eb8-9d0b-be90c3eeb5a6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquipmentExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9efecc3f-6452-46d2-a2c9-9db7b2bba188" xlink:to="loc_us-gaap_EquipmentExpense_c4b85f0a-b54f-4eb8-9d0b-be90c3eeb5a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_5b1bc9aa-4cbd-41a3-a9d9-0d0be85f14ed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9efecc3f-6452-46d2-a2c9-9db7b2bba188" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_5b1bc9aa-4cbd-41a3-a9d9-0d0be85f14ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoninterestExpense_9575516b-8274-480b-a109-7bc04182e303" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNoninterestExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9efecc3f-6452-46d2-a2c9-9db7b2bba188" xlink:to="loc_us-gaap_OtherNoninterestExpense_9575516b-8274-480b-a109-7bc04182e303" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_8b281fd1-92c3-4c4c-8848-ae008506a0e4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_174974c9-42a2-42c8-84de-b29fc1b53b6a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_8b281fd1-92c3-4c4c-8848-ae008506a0e4" xlink:to="loc_us-gaap_InterestExpense_174974c9-42a2-42c8-84de-b29fc1b53b6a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_773d6d66-1648-45dd-811c-c4b0143f6bb4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_8b281fd1-92c3-4c4c-8848-ae008506a0e4" xlink:to="loc_us-gaap_InterestAndDividendIncomeOperating_773d6d66-1648-45dd-811c-c4b0143f6bb4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_ed7cdad9-be5d-4ca7-9539-5fe8c92bfc1b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDeposits_a4fe8d3e-6bec-48dc-95bb-38a655759dad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpenseDeposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_ed7cdad9-be5d-4ca7-9539-5fe8c92bfc1b" xlink:to="loc_us-gaap_InterestExpenseDeposits_a4fe8d3e-6bec-48dc-95bb-38a655759dad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_9302abe1-da55-4204-bfee-398a50e3ecd5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Revenues"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_69d18923-ad84-458b-9421-4af997d09683" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestIncome"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_9302abe1-da55-4204-bfee-398a50e3ecd5" xlink:to="loc_us-gaap_NoninterestIncome_69d18923-ad84-458b-9421-4af997d09683" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_007c56d6-7687-4acc-9724-3c7d95242c64" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_9302abe1-da55-4204-bfee-398a50e3ecd5" xlink:to="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_007c56d6-7687-4acc-9724-3c7d95242c64" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_6b443d37-37cc-4a36-96af-d47978dd38ef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndFeeIncomeLoansAndLeases_ce0117d2-aa47-4ed9-a2a1-09cc7e6cdefb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestAndFeeIncomeLoansAndLeases"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_6b443d37-37cc-4a36-96af-d47978dd38ef" xlink:to="loc_us-gaap_InterestAndFeeIncomeLoansAndLeases_ce0117d2-aa47-4ed9-a2a1-09cc7e6cdefb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesTaxable_e97eddcc-55b5-4715-b38e-0d633ae87834" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeSecuritiesTaxable"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_6b443d37-37cc-4a36-96af-d47978dd38ef" xlink:to="loc_us-gaap_InterestIncomeSecuritiesTaxable_e97eddcc-55b5-4715-b38e-0d633ae87834" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesTaxExempt_f119a560-b09f-41db-a7e5-6353e3c7f16e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeSecuritiesTaxExempt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_6b443d37-37cc-4a36-96af-d47978dd38ef" xlink:to="loc_us-gaap_InterestIncomeSecuritiesTaxExempt_f119a560-b09f-41db-a7e5-6353e3c7f16e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cass_InterestOnFederalFundsSoldAndOtherShortTermInvestments_48e8e086-ddcb-434b-9740-9a84887eb55d" xlink:href="cass-20220331.xsd#cass_InterestOnFederalFundsSoldAndOtherShortTermInvestments"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_6b443d37-37cc-4a36-96af-d47978dd38ef" xlink:to="loc_cass_InterestOnFederalFundsSoldAndOtherShortTermInvestments_48e8e086-ddcb-434b-9740-9a84887eb55d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME" xlink:type="simple" xlink:href="cass-20220331.xsd#CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_ef56e9ae-0b9c-4c26-9a12-f05343390595" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_4bc66741-5ba6-4f58-8899-5ab078c7be96" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_ef56e9ae-0b9c-4c26-9a12-f05343390595" xlink:to="loc_us-gaap_NetIncomeLoss_4bc66741-5ba6-4f58-8899-5ab078c7be96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_872d7f6c-e9f0-4fd6-a0bb-cfabfc3ff212" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_ef56e9ae-0b9c-4c26-9a12-f05343390595" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_872d7f6c-e9f0-4fd6-a0bb-cfabfc3ff212" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_96ad3d51-22ce-4c31-a8bf-b303b8f0c848" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_ef56e9ae-0b9c-4c26-9a12-f05343390595" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_96ad3d51-22ce-4c31-a8bf-b303b8f0c848" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_49f71dd1-0fa7-4820-b2bb-663c99214ea6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_ef56e9ae-0b9c-4c26-9a12-f05343390595" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_49f71dd1-0fa7-4820-b2bb-663c99214ea6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax_21e02709-62e1-4408-82f7-42e292cc1139" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_ef56e9ae-0b9c-4c26-9a12-f05343390595" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax_21e02709-62e1-4408-82f7-42e292cc1139" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_50696917-dbce-44b9-b327-1fd16fb9e175" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_ef56e9ae-0b9c-4c26-9a12-f05343390595" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_50696917-dbce-44b9-b327-1fd16fb9e175" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="cass-20220331.xsd#CONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_798ee3d8-4f3b-4fba-8306-8a98806857c3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_cass_NetIncreaseDecreaseInNoninterestBearingDemandDeposits_a6e7a78f-ddd6-4a21-91d0-d0d72ff96a78" xlink:href="cass-20220331.xsd#cass_NetIncreaseDecreaseInNoninterestBearingDemandDeposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_798ee3d8-4f3b-4fba-8306-8a98806857c3" xlink:to="loc_cass_NetIncreaseDecreaseInNoninterestBearingDemandDeposits_a6e7a78f-ddd6-4a21-91d0-d0d72ff96a78" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cass_IncreaseDecreaseInInterestBearingDemandAndSavingsDeposits_6148e470-3fed-46e4-afcc-da0314169aeb" xlink:href="cass-20220331.xsd#cass_IncreaseDecreaseInInterestBearingDemandAndSavingsDeposits"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_798ee3d8-4f3b-4fba-8306-8a98806857c3" xlink:to="loc_cass_IncreaseDecreaseInInterestBearingDemandAndSavingsDeposits_6148e470-3fed-46e4-afcc-da0314169aeb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInTimeDeposits_b23ae1de-1553-461d-8289-fb1448d761c2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInTimeDeposits"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_798ee3d8-4f3b-4fba-8306-8a98806857c3" xlink:to="loc_us-gaap_IncreaseDecreaseInTimeDeposits_b23ae1de-1553-461d-8289-fb1448d761c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cass_IncreaseDecreaseInAccountsAndDraftsPayable_f360cb9b-fa58-4d9a-9ff3-c88790b17e0b" xlink:href="cass-20220331.xsd#cass_IncreaseDecreaseInAccountsAndDraftsPayable"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_798ee3d8-4f3b-4fba-8306-8a98806857c3" xlink:to="loc_cass_IncreaseDecreaseInAccountsAndDraftsPayable_f360cb9b-fa58-4d9a-9ff3-c88790b17e0b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividendsCommonStock_dd27d808-7d8d-464f-82f7-737a87f8cfd3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDividendsCommonStock"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_798ee3d8-4f3b-4fba-8306-8a98806857c3" xlink:to="loc_us-gaap_PaymentsOfDividendsCommonStock_dd27d808-7d8d-464f-82f7-737a87f8cfd3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_f97145df-05fd-4014-b0f3-e6c62686f709" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_798ee3d8-4f3b-4fba-8306-8a98806857c3" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_f97145df-05fd-4014-b0f3-e6c62686f709" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_76d2e28e-a309-4847-ae78-63e03ff17441" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_798ee3d8-4f3b-4fba-8306-8a98806857c3" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_76d2e28e-a309-4847-ae78-63e03ff17441" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d2518a92-7099-4993-ba67-37277795e5f3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_163dff1a-e48f-49fb-922f-af852541585c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d2518a92-7099-4993-ba67-37277795e5f3" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_163dff1a-e48f-49fb-922f-af852541585c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cass_IncreaseDecreaseInPaymentsInAdvanceOfFunding_efb674d7-7f63-4a06-a1c4-9f4c785af5f8" xlink:href="cass-20220331.xsd#cass_IncreaseDecreaseInPaymentsInAdvanceOfFunding"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d2518a92-7099-4993-ba67-37277795e5f3" xlink:to="loc_cass_IncreaseDecreaseInPaymentsInAdvanceOfFunding_efb674d7-7f63-4a06-a1c4-9f4c785af5f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireLifeInsurancePolicies_c2a4a0b7-8e67-4c27-9008-70ae4f9a4ff3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireLifeInsurancePolicies"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d2518a92-7099-4993-ba67-37277795e5f3" xlink:to="loc_us-gaap_PaymentsToAcquireLifeInsurancePolicies_c2a4a0b7-8e67-4c27-9008-70ae4f9a4ff3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_3da06747-094e-43ab-8ed3-488b8a3f779b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d2518a92-7099-4993-ba67-37277795e5f3" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_3da06747-094e-43ab-8ed3-488b8a3f779b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromLoansAndLeases_5c131661-2c16-4bb5-b383-527f83d305b9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForProceedsFromLoansAndLeases"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d2518a92-7099-4993-ba67-37277795e5f3" xlink:to="loc_us-gaap_PaymentsForProceedsFromLoansAndLeases_5c131661-2c16-4bb5-b383-527f83d305b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_08d1d28e-efc7-4866-ad39-8e2f009aeb83" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d2518a92-7099-4993-ba67-37277795e5f3" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_08d1d28e-efc7-4866-ad39-8e2f009aeb83" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_d44a97f3-3efb-44a1-91c4-bc135f7d63c8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d2518a92-7099-4993-ba67-37277795e5f3" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_d44a97f3-3efb-44a1-91c4-bc135f7d63c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb1b30d0-8944-4ff6-b5d8-2ce9f8f70824" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_b0f92e4f-7de6-49c9-9aa2-baaf29aa7efd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb1b30d0-8944-4ff6-b5d8-2ce9f8f70824" xlink:to="loc_us-gaap_NetIncomeLoss_b0f92e4f-7de6-49c9-9aa2-baaf29aa7efd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAmortizationAndAccretionNet_b7ecb1f8-9a0a-4404-b6f4-53ad1ea93328" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepreciationAmortizationAndAccretionNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb1b30d0-8944-4ff6-b5d8-2ce9f8f70824" xlink:to="loc_us-gaap_DepreciationAmortizationAndAccretionNet_b7ecb1f8-9a0a-4404-b6f4-53ad1ea93328" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtAndEquitySecuritiesGainLoss_f70b3a7e-146f-4840-a19f-749d7b51ce4c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtAndEquitySecuritiesGainLoss"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb1b30d0-8944-4ff6-b5d8-2ce9f8f70824" xlink:to="loc_us-gaap_DebtAndEquitySecuritiesGainLoss_f70b3a7e-146f-4840-a19f-749d7b51ce4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_83f8092f-2f60-40ad-92a4-8a71408a8ee1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb1b30d0-8944-4ff6-b5d8-2ce9f8f70824" xlink:to="loc_us-gaap_ShareBasedCompensation_83f8092f-2f60-40ad-92a4-8a71408a8ee1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_7843d908-23c4-4dc3-a80f-2987d59e7c20" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb1b30d0-8944-4ff6-b5d8-2ce9f8f70824" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_7843d908-23c4-4dc3-a80f-2987d59e7c20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPensionPlanObligations_06ee78fe-2da3-4c2d-842e-567754b39547" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInPensionPlanObligations"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb1b30d0-8944-4ff6-b5d8-2ce9f8f70824" xlink:to="loc_us-gaap_IncreaseDecreaseInPensionPlanObligations_06ee78fe-2da3-4c2d-842e-567754b39547" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_525be2ad-e0b3-43b0-865d-4cfcc27c638e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb1b30d0-8944-4ff6-b5d8-2ce9f8f70824" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_525be2ad-e0b3-43b0-865d-4cfcc27c638e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanLossesExpensed_b85daeaa-ea10-4800-8d74-1b2543f3943d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProvisionForLoanLossesExpensed"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb1b30d0-8944-4ff6-b5d8-2ce9f8f70824" xlink:to="loc_us-gaap_ProvisionForLoanLossesExpensed_b85daeaa-ea10-4800-8d74-1b2543f3943d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_0f36a98a-8403-4d1c-ac05-366e01e19856" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherOperatingActivitiesCashFlowStatement"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb1b30d0-8944-4ff6-b5d8-2ce9f8f70824" xlink:to="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_0f36a98a-8403-4d1c-ac05-366e01e19856" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_5a220dbc-0e48-4f00-b11a-75ca5be2e21f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_887b18e0-d605-4552-8cd0-533cedf63821" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_5a220dbc-0e48-4f00-b11a-75ca5be2e21f" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_887b18e0-d605-4552-8cd0-533cedf63821" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ef3eac22-a501-4335-a430-f762d8b056e1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_5a220dbc-0e48-4f00-b11a-75ca5be2e21f" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ef3eac22-a501-4335-a430-f762d8b056e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4716b0e4-47df-4a71-9a2b-77af60b1e182" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_5a220dbc-0e48-4f00-b11a-75ca5be2e21f" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4716b0e4-47df-4a71-9a2b-77af60b1e182" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/IntangibleAssetsScheduleofIntangibleAssetsandGoodwillDetails" xlink:type="simple" xlink:href="cass-20220331.xsd#IntangibleAssetsScheduleofIntangibleAssetsandGoodwillDetails"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/IntangibleAssetsScheduleofIntangibleAssetsandGoodwillDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_8edaad5c-94ba-44b2-a5f0-3794d0fb19cf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillGross_a3b271d0-ec28-4bba-b006-8ba78467e237" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_8edaad5c-94ba-44b2-a5f0-3794d0fb19cf" xlink:to="loc_us-gaap_GoodwillGross_a3b271d0-ec28-4bba-b006-8ba78467e237" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_4ab90f94-9de2-4040-893c-a246409b834d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_8edaad5c-94ba-44b2-a5f0-3794d0fb19cf" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_4ab90f94-9de2-4040-893c-a246409b834d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/EarningsPerShareDetails" xlink:type="simple" xlink:href="cass-20220331.xsd#EarningsPerShareDetails"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/EarningsPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_d5aea7ef-76e2-4e09-8326-a9d85ead4719" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_e0969b3e-8d22-425a-9bc0-b4741499b583" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_d5aea7ef-76e2-4e09-8326-a9d85ead4719" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_e0969b3e-8d22-425a-9bc0-b4741499b583" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_03e57cd6-318d-4eed-804c-8e2620d3d027" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_d5aea7ef-76e2-4e09-8326-a9d85ead4719" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_03e57cd6-318d-4eed-804c-8e2620d3d027" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/DefinedPensionPlansScheduleofNetPeriodicPensionCostsDetails" xlink:type="simple" xlink:href="cass-20220331.xsd#DefinedPensionPlansScheduleofNetPeriodicPensionCostsDetails"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/DefinedPensionPlansScheduleofNetPeriodicPensionCostsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_882af909-8330-40d4-af25-db6cc0da6263" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_62904a67-d096-4cea-b93c-bf4a7509761e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanServiceCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_882af909-8330-40d4-af25-db6cc0da6263" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_62904a67-d096-4cea-b93c-bf4a7509761e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_bd2b1ec5-51b1-4074-b0f9-a9e32452d720" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanInterestCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_882af909-8330-40d4-af25-db6cc0da6263" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_bd2b1ec5-51b1-4074-b0f9-a9e32452d720" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_471b4c2f-5b05-4c1f-9487-aba739d05b24" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_882af909-8330-40d4-af25-db6cc0da6263" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_471b4c2f-5b05-4c1f-9487-aba739d05b24" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_e64171fb-068a-40b4-8ce0-fdb97dab86c6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_882af909-8330-40d4-af25-db6cc0da6263" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_e64171fb-068a-40b4-8ce0-fdb97dab86c6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/InvestmentinSecuritiesScheduleofInvestmentSecuritiesDetails" xlink:type="simple" xlink:href="cass-20220331.xsd#InvestmentinSecuritiesScheduleofInvestmentSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/InvestmentinSecuritiesScheduleofInvestmentSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_0a79035c-febe-4957-afec-367bfe6a8c5b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_75172307-9d50-443c-ab25-f45d8d97d8f6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_0a79035c-febe-4957-afec-367bfe6a8c5b" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_75172307-9d50-443c-ab25-f45d8d97d8f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_56dbe07c-6672-4fbb-953a-c2f4f5396222" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_0a79035c-febe-4957-afec-367bfe6a8c5b" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_56dbe07c-6672-4fbb-953a-c2f4f5396222" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3ce140a0-b082-40f3-b6e4-0b47a0ef0f70" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_0a79035c-febe-4957-afec-367bfe6a8c5b" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3ce140a0-b082-40f3-b6e4-0b47a0ef0f70" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/InvestmentinSecuritiesScheduleoftheFairValuesofSecuritieswithUnrealizedLossesDetails" xlink:type="simple" xlink:href="cass-20220331.xsd#InvestmentinSecuritiesScheduleoftheFairValuesofSecuritieswithUnrealizedLossesDetails"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/InvestmentinSecuritiesScheduleoftheFairValuesofSecuritieswithUnrealizedLossesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_aabe7c9c-824d-426f-8b48-b747d228e13d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_942f6025-707f-4da1-bc2e-a4515b8e62d0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_aabe7c9c-824d-426f-8b48-b747d228e13d" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_942f6025-707f-4da1-bc2e-a4515b8e62d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_d508c7ce-575e-492f-af49-a506b1d29b65" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_aabe7c9c-824d-426f-8b48-b747d228e13d" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_d508c7ce-575e-492f-af49-a506b1d29b65" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_4f5ce5f8-47cc-49e1-ad47-0488048fa6d1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_c478752a-3481-4682-b657-141ada694465" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_4f5ce5f8-47cc-49e1-ad47-0488048fa6d1" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_c478752a-3481-4682-b657-141ada694465" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_3d3ee70a-e7c2-4cdf-9713-5b52679f48b2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_4f5ce5f8-47cc-49e1-ad47-0488048fa6d1" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_3d3ee70a-e7c2-4cdf-9713-5b52679f48b2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/InvestmentinSecuritiesScheduleofAmortizedCostandFairValueofInvestmentSecuritiesDetails" xlink:type="simple" xlink:href="cass-20220331.xsd#InvestmentinSecuritiesScheduleofAmortizedCostandFairValueofInvestmentSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/InvestmentinSecuritiesScheduleofAmortizedCostandFairValueofInvestmentSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_d2a3432f-c8c1-43dd-bbe5-f74b7428d6d6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_45c5a13c-e044-49b4-b1cf-72bc3581e7d2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_d2a3432f-c8c1-43dd-bbe5-f74b7428d6d6" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_45c5a13c-e044-49b4-b1cf-72bc3581e7d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost_89a09118-15ee-4243-a19a-98a7b35d5967" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_d2a3432f-c8c1-43dd-bbe5-f74b7428d6d6" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost_89a09118-15ee-4243-a19a-98a7b35d5967" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_8bcdef32-7c5b-4efd-ab4e-fd84aa28ee4b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_d2a3432f-c8c1-43dd-bbe5-f74b7428d6d6" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_8bcdef32-7c5b-4efd-ab4e-fd84aa28ee4b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost_0a1ed310-cac7-4b3b-91c9-b871e37217ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_d2a3432f-c8c1-43dd-bbe5-f74b7428d6d6" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost_0a1ed310-cac7-4b3b-91c9-b871e37217ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_8df28ca8-6178-4b2e-b4d0-89cbd3d0eec8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_32110ec8-ecb6-47e9-98d1-a843aa22f4d9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_8df28ca8-6178-4b2e-b4d0-89cbd3d0eec8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_32110ec8-ecb6-47e9-98d1-a843aa22f4d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_78f38cd3-2128-4974-80b4-6f029ac07840" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_8df28ca8-6178-4b2e-b4d0-89cbd3d0eec8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_78f38cd3-2128-4974-80b4-6f029ac07840" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_6e8c2372-e599-4664-a81f-26ac537d32fc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_8df28ca8-6178-4b2e-b4d0-89cbd3d0eec8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_6e8c2372-e599-4664-a81f-26ac537d32fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_b9245bed-9f54-4531-80fb-36bbb8d8c3c0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_8df28ca8-6178-4b2e-b4d0-89cbd3d0eec8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_b9245bed-9f54-4531-80fb-36bbb8d8c3c0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/FairValueofFinancialInstrumentsDetails" xlink:type="simple" xlink:href="cass-20220331.xsd#FairValueofFinancialInstrumentsDetails"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/FairValueofFinancialInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_4c1a4037-3c09-4611-afe0-fb733c2bf959" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsFairValueDisclosure_d0a5ba25-94a5-4bb7-b846-8cf5d05f15ee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepositsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_4c1a4037-3c09-4611-afe0-fb733c2bf959" xlink:to="loc_us-gaap_DepositsFairValueDisclosure_d0a5ba25-94a5-4bb7-b846-8cf5d05f15ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableFairValueDisclosure_1cdec281-258a-4abb-b727-42120cf303ba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsPayableFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_4c1a4037-3c09-4611-afe0-fb733c2bf959" xlink:to="loc_us-gaap_AccountsPayableFairValueDisclosure_1cdec281-258a-4abb-b727-42120cf303ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesFairValueDisclosure_7114618b-5e2c-4a8f-b726-f0de383808ef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedLiabilitiesFairValueDisclosure"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_4c1a4037-3c09-4611-afe0-fb733c2bf959" xlink:to="loc_us-gaap_AccruedLiabilitiesFairValueDisclosure_7114618b-5e2c-4a8f-b726-f0de383808ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_8e9e8e78-637a-4521-a189-9dabb43dac67" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_a54d00a0-9f00-458a-8114-34f31d27bfa4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_8e9e8e78-637a-4521-a189-9dabb43dac67" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_a54d00a0-9f00-458a-8114-34f31d27bfa4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_e4ec7a04-a745-46ca-8a9b-78ee3d278b41" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_8e9e8e78-637a-4521-a189-9dabb43dac67" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_e4ec7a04-a745-46ca-8a9b-78ee3d278b41" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansReceivableFairValueDisclosure_aff92a41-ae2e-4fb1-8b04-b24ef7dbbe68" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansReceivableFairValueDisclosure"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_8e9e8e78-637a-4521-a189-9dabb43dac67" xlink:to="loc_us-gaap_LoansReceivableFairValueDisclosure_aff92a41-ae2e-4fb1-8b04-b24ef7dbbe68" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cass_AccruedInterestReceivableFairValueDisclosure_4f72ffa3-b0e7-4e82-9261-ebb10c249e51" xlink:href="cass-20220331.xsd#cass_AccruedInterestReceivableFairValueDisclosure"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_8e9e8e78-637a-4521-a189-9dabb43dac67" xlink:to="loc_cass_AccruedInterestReceivableFairValueDisclosure_4f72ffa3-b0e7-4e82-9261-ebb10c249e51" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/RevenuefromContractswithCustomersDetails" xlink:type="simple" xlink:href="cass-20220331.xsd#RevenuefromContractswithCustomersDetails"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/RevenuefromContractswithCustomersDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_9c9b2361-2531-47af-a5cd-498e67b7a078" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_70e9863e-0fa3-4761-885f-5fb0a19ea4c4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_9c9b2361-2531-47af-a5cd-498e67b7a078" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_70e9863e-0fa3-4761-885f-5fb0a19ea4c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueNotFromContractWithCustomer_a7843dbd-39ec-4675-b343-56114b2d91ec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueNotFromContractWithCustomer"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_9c9b2361-2531-47af-a5cd-498e67b7a078" xlink:to="loc_us-gaap_RevenueNotFromContractWithCustomer_a7843dbd-39ec-4675-b343-56114b2d91ec" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/LeasesScheduleofOperatingLeaseMaturityDetails" xlink:type="simple" xlink:href="cass-20220331.xsd#LeasesScheduleofOperatingLeaseMaturityDetails"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/LeasesScheduleofOperatingLeaseMaturityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_8986af08-7851-4411-884b-b0a3a01689ec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_f4f8e6f9-5bcb-4447-aba7-e83324fbb582" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_8986af08-7851-4411-884b-b0a3a01689ec" xlink:to="loc_us-gaap_OperatingLeaseLiability_f4f8e6f9-5bcb-4447-aba7-e83324fbb582" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_484b1722-b12d-4371-b98b-27c04c9b9b18" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_8986af08-7851-4411-884b-b0a3a01689ec" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_484b1722-b12d-4371-b98b-27c04c9b9b18" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/LeasesScheduleofOperatingLeaseMaturityDetails_1" xlink:type="simple" xlink:href="cass-20220331.xsd#LeasesScheduleofOperatingLeaseMaturityDetails_1"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/LeasesScheduleofOperatingLeaseMaturityDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_6e8cb96c-4a21-4277-8383-ee833639c9d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_f4092bc3-05ee-44ca-872e-3c9858452386" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_6e8cb96c-4a21-4277-8383-ee833639c9d3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_f4092bc3-05ee-44ca-872e-3c9858452386" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_341e1505-f9b6-4287-a593-ce9ef1053d79" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_6e8cb96c-4a21-4277-8383-ee833639c9d3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_341e1505-f9b6-4287-a593-ce9ef1053d79" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_8f9c9541-de3f-4782-926f-2e91270d3599" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_6e8cb96c-4a21-4277-8383-ee833639c9d3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_8f9c9541-de3f-4782-926f-2e91270d3599" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_6d0619b4-153a-4f9e-bccd-e41f198ba640" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_6e8cb96c-4a21-4277-8383-ee833639c9d3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_6d0619b4-153a-4f9e-bccd-e41f198ba640" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_8e693ab5-ef2a-4521-aad3-65a47bb67250" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_6e8cb96c-4a21-4277-8383-ee833639c9d3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_8e693ab5-ef2a-4521-aad3-65a47bb67250" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cass_LesseeOperatingLeaseLiabilityToBePaidDueAfterYearFour_c99ec245-11d7-4e5f-a8b4-6ba94abbcda7" xlink:href="cass-20220331.xsd#cass_LesseeOperatingLeaseLiabilityToBePaidDueAfterYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_6e8cb96c-4a21-4277-8383-ee833639c9d3" xlink:to="loc_cass_LesseeOperatingLeaseLiabilityToBePaidDueAfterYearFour_c99ec245-11d7-4e5f-a8b4-6ba94abbcda7" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
