<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:b8eb6119-e9c7-4654-9f7e-d80b45bf28b3,g:e5bb0178-3407-4eaf-bb59-0808d74c4369-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://cassinfo.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="cass-20220930.xsd#CONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_8e01c989-e18e-4365-87d9-89b8223fea3a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsAndShortTermInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndDueFromBanks_1fce39b4-43d3-49d4-ae17-a4d004985526" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndDueFromBanks"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_8e01c989-e18e-4365-87d9-89b8223fea3a" xlink:to="loc_us-gaap_CashAndDueFromBanks_1fce39b4-43d3-49d4-ae17-a4d004985526" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_5e7430f8-f3fa-4d23-88a4-49f205fbc494" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortTermInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_8e01c989-e18e-4365-87d9-89b8223fea3a" xlink:to="loc_us-gaap_ShortTermInvestments_5e7430f8-f3fa-4d23-88a4-49f205fbc494" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_0076d81b-3090-4a54-b24f-d62f68ff08dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_c539fca0-6a45-4dd7-bce6-a529f260ba30" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsAndShortTermInvestments"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_0076d81b-3090-4a54-b24f-d62f68ff08dc" xlink:to="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_c539fca0-6a45-4dd7-bce6-a529f260ba30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_23373ffd-85b1-4822-894d-5d451b4c18da" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_0076d81b-3090-4a54-b24f-d62f68ff08dc" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_23373ffd-85b1-4822-894d-5d451b4c18da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_6f212198-9954-4e8a-ad3b-597aad9b8ae8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_0076d81b-3090-4a54-b24f-d62f68ff08dc" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_6f212198-9954-4e8a-ad3b-597aad9b8ae8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_79b28143-6bc0-4120-aa02-63000ff07001" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_0076d81b-3090-4a54-b24f-d62f68ff08dc" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_79b28143-6bc0-4120-aa02-63000ff07001" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankOwnedLifeInsurance_c219928f-8846-4837-9eb9-37440523c087" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BankOwnedLifeInsurance"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_0076d81b-3090-4a54-b24f-d62f68ff08dc" xlink:to="loc_us-gaap_BankOwnedLifeInsurance_c219928f-8846-4837-9eb9-37440523c087" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cass_PaymentsInAdvanceOfFunding_7cbc78b4-b3a6-4ba1-b2be-cecf3687cb54" xlink:href="cass-20220930.xsd#cass_PaymentsInAdvanceOfFunding"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_0076d81b-3090-4a54-b24f-d62f68ff08dc" xlink:to="loc_cass_PaymentsInAdvanceOfFunding_7cbc78b4-b3a6-4ba1-b2be-cecf3687cb54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_2cfc1776-0676-49f4-92ec-abed40726c91" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_0076d81b-3090-4a54-b24f-d62f68ff08dc" xlink:to="loc_us-gaap_Goodwill_2cfc1776-0676-49f4-92ec-abed40726c91" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_b798d5fd-9d95-4573-8233-2601b626d1d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_0076d81b-3090-4a54-b24f-d62f68ff08dc" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_b798d5fd-9d95-4573-8233-2601b626d1d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssets_12060311-74df-40df-926f-13bb36ffdd29" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssets"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_0076d81b-3090-4a54-b24f-d62f68ff08dc" xlink:to="loc_us-gaap_OtherAssets_12060311-74df-40df-926f-13bb36ffdd29" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_796216fc-569b-4a3e-a346-367694622f44" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_cd532c0b-31f1-4b88-bcfb-7ef656b51ae2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_796216fc-569b-4a3e-a346-367694622f44" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_cd532c0b-31f1-4b88-bcfb-7ef656b51ae2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest_ddf23685-b73b-416f-85ab-022f67974f7c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_796216fc-569b-4a3e-a346-367694622f44" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest_ddf23685-b73b-416f-85ab-022f67974f7c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_cd43ffbf-0227-42a8-a3d2-3f185028dce4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_8702d0a4-813d-46ef-b973-a70367edca10" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Deposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_cd43ffbf-0227-42a8-a3d2-3f185028dce4" xlink:to="loc_us-gaap_Deposits_8702d0a4-813d-46ef-b973-a70367edca10" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cass_AccountsAndDraftsPayable_4a651da9-8da0-484b-b0e9-c2750f0a1472" xlink:href="cass-20220930.xsd#cass_AccountsAndDraftsPayable"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_cd43ffbf-0227-42a8-a3d2-3f185028dce4" xlink:to="loc_cass_AccountsAndDraftsPayable_4a651da9-8da0-484b-b0e9-c2750f0a1472" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilities_4795ad2c-3736-461d-bb60-de8a972f7b6a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_cd43ffbf-0227-42a8-a3d2-3f185028dce4" xlink:to="loc_us-gaap_OtherLiabilities_4795ad2c-3736-461d-bb60-de8a972f7b6a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_267d5cf0-69c9-4135-a4b7-2c2712a3fc1b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_43f73477-5d20-4893-9fe2-9c23fe8b1b42" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_267d5cf0-69c9-4135-a4b7-2c2712a3fc1b" xlink:to="loc_us-gaap_Liabilities_43f73477-5d20-4893-9fe2-9c23fe8b1b42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_e13f7734-f123-4f57-ac3b-cac402dbf12c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_267d5cf0-69c9-4135-a4b7-2c2712a3fc1b" xlink:to="loc_us-gaap_StockholdersEquity_e13f7734-f123-4f57-ac3b-cac402dbf12c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_b4885890-aeb2-4164-9580-855439122f74" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Deposits"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestBearingDepositLiabilities_c36d7de4-fe4f-4b43-a2d0-b0a7fcce9ee3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoninterestBearingDepositLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_b4885890-aeb2-4164-9580-855439122f74" xlink:to="loc_us-gaap_NoninterestBearingDepositLiabilities_c36d7de4-fe4f-4b43-a2d0-b0a7fcce9ee3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestBearingDepositLiabilities_55dec0b7-7708-4e61-b9ae-e5fd83ed48fb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestBearingDepositLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_b4885890-aeb2-4164-9580-855439122f74" xlink:to="loc_us-gaap_InterestBearingDepositLiabilities_55dec0b7-7708-4e61-b9ae-e5fd83ed48fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_744d200d-5aff-431d-82e6-fd2de359bd14" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_53e3f686-827a-401e-b3df-b2eac36b6c88" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_744d200d-5aff-431d-82e6-fd2de359bd14" xlink:to="loc_us-gaap_PreferredStockValue_53e3f686-827a-401e-b3df-b2eac36b6c88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValueOutstanding_075817da-aaeb-492e-b8da-2ed08a6c1919" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValueOutstanding"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_744d200d-5aff-431d-82e6-fd2de359bd14" xlink:to="loc_us-gaap_CommonStockValueOutstanding_075817da-aaeb-492e-b8da-2ed08a6c1919" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_64ffef14-f2ca-4a51-a202-df8611bff8b7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_744d200d-5aff-431d-82e6-fd2de359bd14" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_64ffef14-f2ca-4a51-a202-df8611bff8b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_3de5e29e-8fd7-45e4-a7fd-d6015dfa3e39" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_744d200d-5aff-431d-82e6-fd2de359bd14" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_3de5e29e-8fd7-45e4-a7fd-d6015dfa3e39" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_6e85d8b6-7044-4e17-aec8-d9a18dd2635d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_744d200d-5aff-431d-82e6-fd2de359bd14" xlink:to="loc_us-gaap_TreasuryStockValue_6e85d8b6-7044-4e17-aec8-d9a18dd2635d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_79354c32-dfe7-4542-9358-2580707647b8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_744d200d-5aff-431d-82e6-fd2de359bd14" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_79354c32-dfe7-4542-9358-2580707647b8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/CONSOLIDATEDSTATEMENTSOFINCOME" xlink:type="simple" xlink:href="cass-20220930.xsd#CONSOLIDATEDSTATEMENTSOFINCOME"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/CONSOLIDATEDSTATEMENTSOFINCOME" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_a877c0ab-bffd-49eb-ac53-eea00427c5ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_bd57b50b-2687-4cc1-b756-5feb3735ce23" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_a877c0ab-bffd-49eb-ac53-eea00427c5ab" xlink:to="loc_us-gaap_InterestExpense_bd57b50b-2687-4cc1-b756-5feb3735ce23" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_cfabe07f-8cad-4073-93e1-390719cb2341" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_a877c0ab-bffd-49eb-ac53-eea00427c5ab" xlink:to="loc_us-gaap_InterestAndDividendIncomeOperating_cfabe07f-8cad-4073-93e1-390719cb2341" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_8dd88668-ed66-4627-95a4-677c471e4abb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoninterestIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_597163e2-5306-4944-b51d-90359cc26634" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_8dd88668-ed66-4627-95a4-677c471e4abb" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_597163e2-5306-4944-b51d-90359cc26634" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueNotFromContractWithCustomerOther_af42a9d9-9751-44d3-ad38-9eef77141fa2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueNotFromContractWithCustomerOther"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_8dd88668-ed66-4627-95a4-677c471e4abb" xlink:to="loc_us-gaap_RevenueNotFromContractWithCustomerOther_af42a9d9-9751-44d3-ad38-9eef77141fa2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_2fd34130-db4a-45bd-b258-48919308a847" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_3b542de7-2f68-4e26-b763-8a9e3cfdbaab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_2fd34130-db4a-45bd-b258-48919308a847" xlink:to="loc_us-gaap_InterestIncomeExpenseNet_3b542de7-2f68-4e26-b763-8a9e3cfdbaab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanLossesExpensed_855925e9-0b0b-4566-9a5a-44ed4dd5b5c3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProvisionForLoanLossesExpensed"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_2fd34130-db4a-45bd-b258-48919308a847" xlink:to="loc_us-gaap_ProvisionForLoanLossesExpensed_855925e9-0b0b-4566-9a5a-44ed4dd5b5c3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_d50ce220-10ea-4c5b-8f75-22bfa6c2dde5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_4ea2a15b-d538-47ee-84b7-bce85b9fcf42" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_d50ce220-10ea-4c5b-8f75-22bfa6c2dde5" xlink:to="loc_us-gaap_Revenues_4ea2a15b-d538-47ee-84b7-bce85b9fcf42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_37f820e1-e543-47a7-aca2-794fba1fb672" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoninterestExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_d50ce220-10ea-4c5b-8f75-22bfa6c2dde5" xlink:to="loc_us-gaap_NoninterestExpense_37f820e1-e543-47a7-aca2-794fba1fb672" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_09345cd3-9f31-463a-bd5c-5c3cfbfea2d5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Revenues"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_ccec588b-7520-4551-bca0-826ca2d70607" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoninterestIncome"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_09345cd3-9f31-463a-bd5c-5c3cfbfea2d5" xlink:to="loc_us-gaap_NoninterestIncome_ccec588b-7520-4551-bca0-826ca2d70607" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_f204a2f7-bb76-407d-bb8a-badfdf210062" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_09345cd3-9f31-463a-bd5c-5c3cfbfea2d5" xlink:to="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_f204a2f7-bb76-407d-bb8a-badfdf210062" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_ef7523ab-010e-4f62-9312-225a035fdc4b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoninterestExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_97278bad-816c-49fe-873d-9840db8f9643" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_ef7523ab-010e-4f62-9312-225a035fdc4b" xlink:to="loc_us-gaap_LaborAndRelatedExpense_97278bad-816c-49fe-873d-9840db8f9643" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OccupancyNet_44525e36-395f-4300-822e-49171bf67fa6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OccupancyNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_ef7523ab-010e-4f62-9312-225a035fdc4b" xlink:to="loc_us-gaap_OccupancyNet_44525e36-395f-4300-822e-49171bf67fa6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquipmentExpense_4ecb4dd7-acb0-41cd-b84c-35010fd123bc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquipmentExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_ef7523ab-010e-4f62-9312-225a035fdc4b" xlink:to="loc_us-gaap_EquipmentExpense_4ecb4dd7-acb0-41cd-b84c-35010fd123bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_a1f803af-07f5-4fbd-a039-5ced64f8591e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_ef7523ab-010e-4f62-9312-225a035fdc4b" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_a1f803af-07f5-4fbd-a039-5ced64f8591e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoninterestExpense_43d71973-f236-4307-b2df-e3f932e40ba9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNoninterestExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_ef7523ab-010e-4f62-9312-225a035fdc4b" xlink:to="loc_us-gaap_OtherNoninterestExpense_43d71973-f236-4307-b2df-e3f932e40ba9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_2ecf7098-57ee-4766-b0d8-e42871b95c42" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_d1d8ee6e-2123-4009-afab-753e2517f604" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_2ecf7098-57ee-4766-b0d8-e42871b95c42" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_d1d8ee6e-2123-4009-afab-753e2517f604" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_8dc56b9c-dba8-4f05-8050-09da4e8b76c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_2ecf7098-57ee-4766-b0d8-e42871b95c42" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_8dc56b9c-dba8-4f05-8050-09da4e8b76c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_74ce9f6a-f9f2-4cf4-8576-ac2e31a3e4fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndFeeIncomeLoansAndLeases_1bc03213-265d-41c8-9416-00b333336ddd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestAndFeeIncomeLoansAndLeases"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_74ce9f6a-f9f2-4cf4-8576-ac2e31a3e4fd" xlink:to="loc_us-gaap_InterestAndFeeIncomeLoansAndLeases_1bc03213-265d-41c8-9416-00b333336ddd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesTaxable_89691394-9a17-4447-9956-e25283c47e34" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeSecuritiesTaxable"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_74ce9f6a-f9f2-4cf4-8576-ac2e31a3e4fd" xlink:to="loc_us-gaap_InterestIncomeSecuritiesTaxable_89691394-9a17-4447-9956-e25283c47e34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesTaxExempt_0b3c72d3-163f-45c4-b40e-93979a30d998" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeSecuritiesTaxExempt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_74ce9f6a-f9f2-4cf4-8576-ac2e31a3e4fd" xlink:to="loc_us-gaap_InterestIncomeSecuritiesTaxExempt_0b3c72d3-163f-45c4-b40e-93979a30d998" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cass_InterestOnFederalFundsSoldAndOtherShortTermInvestments_b017aac2-13f9-4e15-a169-a7b296d7cc8c" xlink:href="cass-20220930.xsd#cass_InterestOnFederalFundsSoldAndOtherShortTermInvestments"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_74ce9f6a-f9f2-4cf4-8576-ac2e31a3e4fd" xlink:to="loc_cass_InterestOnFederalFundsSoldAndOtherShortTermInvestments_b017aac2-13f9-4e15-a169-a7b296d7cc8c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_f7221757-51f6-48eb-9065-1c724b4c87a0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDeposits_489d375b-2276-4f6a-85f9-91cd58856b72" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpenseDeposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_f7221757-51f6-48eb-9065-1c724b4c87a0" xlink:to="loc_us-gaap_InterestExpenseDeposits_489d375b-2276-4f6a-85f9-91cd58856b72" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME" xlink:type="simple" xlink:href="cass-20220930.xsd#CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_93349984-4bf8-4de4-a0fe-a8280f892590" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_46d283f8-7ff1-4b1e-8b81-53fff20a7b89" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_93349984-4bf8-4de4-a0fe-a8280f892590" xlink:to="loc_us-gaap_NetIncomeLoss_46d283f8-7ff1-4b1e-8b81-53fff20a7b89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_f8a6c2bc-72d8-4226-8345-04776c40cebc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_93349984-4bf8-4de4-a0fe-a8280f892590" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_f8a6c2bc-72d8-4226-8345-04776c40cebc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_944f07c4-9daa-48c0-9e8b-c51bfb54384e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_93349984-4bf8-4de4-a0fe-a8280f892590" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_944f07c4-9daa-48c0-9e8b-c51bfb54384e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_fffbe69e-a63e-401a-9207-afc7c0a4f9ac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_93349984-4bf8-4de4-a0fe-a8280f892590" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_fffbe69e-a63e-401a-9207-afc7c0a4f9ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax_9e03746c-f6e8-420d-a622-45664e637acc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_93349984-4bf8-4de4-a0fe-a8280f892590" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax_9e03746c-f6e8-420d-a622-45664e637acc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_60dad2e6-d37d-425c-abdb-2103e4b91fcf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_93349984-4bf8-4de4-a0fe-a8280f892590" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_60dad2e6-d37d-425c-abdb-2103e4b91fcf" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="cass-20220930.xsd#CONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_3613f6c3-94a4-442c-b012-01788ef9e2c0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_dfce0a6a-7b0e-4b02-a2cf-1e64aff8f56f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_3613f6c3-94a4-442c-b012-01788ef9e2c0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_dfce0a6a-7b0e-4b02-a2cf-1e64aff8f56f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d2170934-ae94-4a0d-9cad-4ce0ce654d57" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_3613f6c3-94a4-442c-b012-01788ef9e2c0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d2170934-ae94-4a0d-9cad-4ce0ce654d57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ee68f445-17ee-4f63-84ac-39bbb8dd1101" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_3613f6c3-94a4-442c-b012-01788ef9e2c0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ee68f445-17ee-4f63-84ac-39bbb8dd1101" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6949c18f-6a4b-484b-b209-97d10c109396" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_189656d6-db3a-47d9-9094-e062c1fa6755" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6949c18f-6a4b-484b-b209-97d10c109396" xlink:to="loc_us-gaap_NetIncomeLoss_189656d6-db3a-47d9-9094-e062c1fa6755" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAmortizationAndAccretionNet_94fe6f52-cb02-409e-abf7-0e9d2c194502" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepreciationAmortizationAndAccretionNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6949c18f-6a4b-484b-b209-97d10c109396" xlink:to="loc_us-gaap_DepreciationAmortizationAndAccretionNet_94fe6f52-cb02-409e-abf7-0e9d2c194502" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtAndEquitySecuritiesGainLoss_d126fa5e-83d4-448a-9496-ad1999de14d2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtAndEquitySecuritiesGainLoss"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6949c18f-6a4b-484b-b209-97d10c109396" xlink:to="loc_us-gaap_DebtAndEquitySecuritiesGainLoss_d126fa5e-83d4-448a-9496-ad1999de14d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_bf8e6043-7d0d-49b0-b7de-793f9b681699" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6949c18f-6a4b-484b-b209-97d10c109396" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_bf8e6043-7d0d-49b0-b7de-793f9b681699" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanLossesExpensed_b531369c-7c51-49ef-9895-40925b7cf3af" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProvisionForLoanLossesExpensed"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6949c18f-6a4b-484b-b209-97d10c109396" xlink:to="loc_us-gaap_ProvisionForLoanLossesExpensed_b531369c-7c51-49ef-9895-40925b7cf3af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_5c62eba5-3f00-4f1e-b430-28e2ac00a647" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherOperatingActivitiesCashFlowStatement"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6949c18f-6a4b-484b-b209-97d10c109396" xlink:to="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_5c62eba5-3f00-4f1e-b430-28e2ac00a647" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPensionPlanObligations_9ccfa483-5e46-4547-b909-fdbeac5bb4d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInPensionPlanObligations"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6949c18f-6a4b-484b-b209-97d10c109396" xlink:to="loc_us-gaap_IncreaseDecreaseInPensionPlanObligations_9ccfa483-5e46-4547-b909-fdbeac5bb4d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_0bf400e3-5e62-42f3-8e02-c0dd35b962d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6949c18f-6a4b-484b-b209-97d10c109396" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_0bf400e3-5e62-42f3-8e02-c0dd35b962d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_916be90a-de81-4883-bc49-cccbb46f5467" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6949c18f-6a4b-484b-b209-97d10c109396" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_916be90a-de81-4883-bc49-cccbb46f5467" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_3492d952-7180-4474-9161-d7ec4bda742a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_6949c18f-6a4b-484b-b209-97d10c109396" xlink:to="loc_us-gaap_ShareBasedCompensation_3492d952-7180-4474-9161-d7ec4bda742a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b6123a30-9284-45fd-a59e-a9f1dbcbdc8c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_0c6dbff8-3ae5-449d-9255-aa1c32071563" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b6123a30-9284-45fd-a59e-a9f1dbcbdc8c" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_0c6dbff8-3ae5-449d-9255-aa1c32071563" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_08c44d28-36a3-42d2-8264-9c53aad82af0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b6123a30-9284-45fd-a59e-a9f1dbcbdc8c" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_08c44d28-36a3-42d2-8264-9c53aad82af0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_93bc040b-808c-4286-9bd5-6e81e8035124" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b6123a30-9284-45fd-a59e-a9f1dbcbdc8c" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_93bc040b-808c-4286-9bd5-6e81e8035124" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cass_DecreaseIncreaseInPaymentsInAdvanceOfFunding_43d0477a-c8e0-4f44-8e14-c4153ec16a88" xlink:href="cass-20220930.xsd#cass_DecreaseIncreaseInPaymentsInAdvanceOfFunding"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b6123a30-9284-45fd-a59e-a9f1dbcbdc8c" xlink:to="loc_cass_DecreaseIncreaseInPaymentsInAdvanceOfFunding_43d0477a-c8e0-4f44-8e14-c4153ec16a88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_5f0098cd-b09e-447d-912a-71194a84c4ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b6123a30-9284-45fd-a59e-a9f1dbcbdc8c" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_5f0098cd-b09e-447d-912a-71194a84c4ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromLoansAndLeases_b873c64f-3155-4c5e-9300-2f73855817c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsForProceedsFromLoansAndLeases"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b6123a30-9284-45fd-a59e-a9f1dbcbdc8c" xlink:to="loc_us-gaap_PaymentsForProceedsFromLoansAndLeases_b873c64f-3155-4c5e-9300-2f73855817c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireLifeInsurancePolicies_01615504-0057-4aac-a00b-538b706fd235" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireLifeInsurancePolicies"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b6123a30-9284-45fd-a59e-a9f1dbcbdc8c" xlink:to="loc_us-gaap_PaymentsToAcquireLifeInsurancePolicies_01615504-0057-4aac-a00b-538b706fd235" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_30139f7d-29ce-4afb-b4cd-e42688b78e9b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b6123a30-9284-45fd-a59e-a9f1dbcbdc8c" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_30139f7d-29ce-4afb-b4cd-e42688b78e9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d03bf994-3f0d-4d81-9d7f-785bb9d10dca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_cass_NetDecreaseInNoninterestBearingDemandDeposits_3d223ee8-be8c-4ffc-a678-e1149a49d243" xlink:href="cass-20220930.xsd#cass_NetDecreaseInNoninterestBearingDemandDeposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d03bf994-3f0d-4d81-9d7f-785bb9d10dca" xlink:to="loc_cass_NetDecreaseInNoninterestBearingDemandDeposits_3d223ee8-be8c-4ffc-a678-e1149a49d243" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cass_IncreaseDecreaseInInterestBearingDemandAndSavingsDeposits_9e3266a1-dbf8-4a79-a8a0-742907acdd87" xlink:href="cass-20220930.xsd#cass_IncreaseDecreaseInInterestBearingDemandAndSavingsDeposits"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d03bf994-3f0d-4d81-9d7f-785bb9d10dca" xlink:to="loc_cass_IncreaseDecreaseInInterestBearingDemandAndSavingsDeposits_9e3266a1-dbf8-4a79-a8a0-742907acdd87" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInTimeDeposits_6337c93a-d7ea-42a2-8b9b-8a2b969b48ba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInTimeDeposits"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d03bf994-3f0d-4d81-9d7f-785bb9d10dca" xlink:to="loc_us-gaap_IncreaseDecreaseInTimeDeposits_6337c93a-d7ea-42a2-8b9b-8a2b969b48ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cass_IncreaseInAccountsAndDraftsPayable_daa4e60c-5b67-4b9b-a4f0-3178934ec8e1" xlink:href="cass-20220930.xsd#cass_IncreaseInAccountsAndDraftsPayable"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d03bf994-3f0d-4d81-9d7f-785bb9d10dca" xlink:to="loc_cass_IncreaseInAccountsAndDraftsPayable_daa4e60c-5b67-4b9b-a4f0-3178934ec8e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividendsCommonStock_47915391-ca9d-4363-bce2-f9cb3e2fa2f5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsOfDividendsCommonStock"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d03bf994-3f0d-4d81-9d7f-785bb9d10dca" xlink:to="loc_us-gaap_PaymentsOfDividendsCommonStock_47915391-ca9d-4363-bce2-f9cb3e2fa2f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_3637cb47-aaf8-4647-96be-e53b842483ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d03bf994-3f0d-4d81-9d7f-785bb9d10dca" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_3637cb47-aaf8-4647-96be-e53b842483ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_8ed63bff-0228-45c1-b801-9e763bb1e874" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d03bf994-3f0d-4d81-9d7f-785bb9d10dca" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_8ed63bff-0228-45c1-b801-9e763bb1e874" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/IntangibleAssetsScheduleofIntangibleAssetsandGoodwillDetails" xlink:type="simple" xlink:href="cass-20220930.xsd#IntangibleAssetsScheduleofIntangibleAssetsandGoodwillDetails"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/IntangibleAssetsScheduleofIntangibleAssetsandGoodwillDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_8feb31a9-ee73-4a1a-a0bf-134584ae733e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillGross_eadd4a0c-e560-4c1c-a579-faf3f3cba4bf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_8feb31a9-ee73-4a1a-a0bf-134584ae733e" xlink:to="loc_us-gaap_GoodwillGross_eadd4a0c-e560-4c1c-a579-faf3f3cba4bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_4e2e2e2a-813d-4a18-a1b1-372d42258e85" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_8feb31a9-ee73-4a1a-a0bf-134584ae733e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_4e2e2e2a-813d-4a18-a1b1-372d42258e85" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/EarningsPerShareDetails" xlink:type="simple" xlink:href="cass-20220930.xsd#EarningsPerShareDetails"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/EarningsPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_c4ba9128-975d-4fb3-a502-74a5391945e8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_35afef4d-4f11-488e-9f30-82f5d80d2bbb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_c4ba9128-975d-4fb3-a502-74a5391945e8" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_35afef4d-4f11-488e-9f30-82f5d80d2bbb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_46131932-399a-4ff6-8574-cf2fd41c013c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_c4ba9128-975d-4fb3-a502-74a5391945e8" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_46131932-399a-4ff6-8574-cf2fd41c013c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/DefinedPensionPlansScheduleofNetPeriodicPensionCostsDetails" xlink:type="simple" xlink:href="cass-20220930.xsd#DefinedPensionPlansScheduleofNetPeriodicPensionCostsDetails"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/DefinedPensionPlansScheduleofNetPeriodicPensionCostsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_1c089793-1094-416b-aa2b-702c253cf9cd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_6cf1f268-3b5e-446f-b2de-8a7ba2ed0788" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanServiceCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_1c089793-1094-416b-aa2b-702c253cf9cd" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_6cf1f268-3b5e-446f-b2de-8a7ba2ed0788" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_48de2c03-b518-4457-8b46-91bb7d4885eb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanInterestCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_1c089793-1094-416b-aa2b-702c253cf9cd" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_48de2c03-b518-4457-8b46-91bb7d4885eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_a2a8ce34-1ce3-4d70-83d0-76412c959f95" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_1c089793-1094-416b-aa2b-702c253cf9cd" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_a2a8ce34-1ce3-4d70-83d0-76412c959f95" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_f6fac5d0-e06b-4e7d-877a-44340014a688" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_1c089793-1094-416b-aa2b-702c253cf9cd" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_f6fac5d0-e06b-4e7d-877a-44340014a688" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/InvestmentinSecuritiesScheduleofInvestmentSecuritiesDetails" xlink:type="simple" xlink:href="cass-20220930.xsd#InvestmentinSecuritiesScheduleofInvestmentSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/InvestmentinSecuritiesScheduleofInvestmentSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_f87ac975-0643-4f41-a4aa-a09aefac3f28" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_a8ed072c-6e46-447b-a47c-443d46da8b5f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_f87ac975-0643-4f41-a4aa-a09aefac3f28" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_a8ed072c-6e46-447b-a47c-443d46da8b5f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_98cdbeff-73c8-46e3-ad6f-d06ca6ba36d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_f87ac975-0643-4f41-a4aa-a09aefac3f28" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_98cdbeff-73c8-46e3-ad6f-d06ca6ba36d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_ee1c7a42-bff0-4b2f-9337-ee7d2466bbd7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_f87ac975-0643-4f41-a4aa-a09aefac3f28" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_ee1c7a42-bff0-4b2f-9337-ee7d2466bbd7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/InvestmentinSecuritiesScheduleoftheFairValuesofSecuritieswithUnrealizedLossesDetails" xlink:type="simple" xlink:href="cass-20220930.xsd#InvestmentinSecuritiesScheduleoftheFairValuesofSecuritieswithUnrealizedLossesDetails"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/InvestmentinSecuritiesScheduleoftheFairValuesofSecuritieswithUnrealizedLossesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_41b721d2-cbb0-40c8-81b7-3349c296d55b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_4e4b2511-2158-4fe4-be04-b1e58693422c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_41b721d2-cbb0-40c8-81b7-3349c296d55b" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_4e4b2511-2158-4fe4-be04-b1e58693422c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_f54f4479-a595-4835-9be6-71b709b2c52f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_41b721d2-cbb0-40c8-81b7-3349c296d55b" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_f54f4479-a595-4835-9be6-71b709b2c52f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_0cc69bb7-9ab5-4c7e-85fc-4d0226d545c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_34a55ac4-8025-42b4-a25b-592ea4d91c61" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_0cc69bb7-9ab5-4c7e-85fc-4d0226d545c6" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_34a55ac4-8025-42b4-a25b-592ea4d91c61" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_564dfcfd-8b9c-46d1-9ec2-3278b1606e73" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_0cc69bb7-9ab5-4c7e-85fc-4d0226d545c6" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_564dfcfd-8b9c-46d1-9ec2-3278b1606e73" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/InvestmentinSecuritiesScheduleofAmortizedCostandFairValueofInvestmentSecuritiesDetails" xlink:type="simple" xlink:href="cass-20220930.xsd#InvestmentinSecuritiesScheduleofAmortizedCostandFairValueofInvestmentSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/InvestmentinSecuritiesScheduleofAmortizedCostandFairValueofInvestmentSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_0db7709c-32ea-4462-a6ac-123671f22f3f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_7134555e-8623-49f0-ba46-21f0f1d1ebca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_0db7709c-32ea-4462-a6ac-123671f22f3f" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_7134555e-8623-49f0-ba46-21f0f1d1ebca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_93aa0753-d4d2-4372-ae3e-5fc7cf8048bc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_0db7709c-32ea-4462-a6ac-123671f22f3f" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_93aa0753-d4d2-4372-ae3e-5fc7cf8048bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_63604543-bc06-43e4-8324-95bba53ea8db" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_0db7709c-32ea-4462-a6ac-123671f22f3f" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_63604543-bc06-43e4-8324-95bba53ea8db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_01044ca8-3a68-4a7a-b080-b090696d91ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_0db7709c-32ea-4462-a6ac-123671f22f3f" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_01044ca8-3a68-4a7a-b080-b090696d91ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_a9f338a0-28ff-40f5-9a4b-155bdb8a5fe8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_a3e3622f-3f09-4d61-94cc-21b355a2d688" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_a9f338a0-28ff-40f5-9a4b-155bdb8a5fe8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_a3e3622f-3f09-4d61-94cc-21b355a2d688" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost_70b55aa2-f9eb-4b2e-a1fb-6ef7959d4c54" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_a9f338a0-28ff-40f5-9a4b-155bdb8a5fe8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost_70b55aa2-f9eb-4b2e-a1fb-6ef7959d4c54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_aa5bc9c9-c7e5-451a-a48f-83f13c8f620b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_a9f338a0-28ff-40f5-9a4b-155bdb8a5fe8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_aa5bc9c9-c7e5-451a-a48f-83f13c8f620b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost_2bfe1a2e-ee84-459b-80b1-4172e763c3e9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_a9f338a0-28ff-40f5-9a4b-155bdb8a5fe8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost_2bfe1a2e-ee84-459b-80b1-4172e763c3e9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/FairValueofFinancialInstrumentsDetails" xlink:type="simple" xlink:href="cass-20220930.xsd#FairValueofFinancialInstrumentsDetails"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/FairValueofFinancialInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_4f3cb5e7-2c39-4d12-ac91-fd178d8f1762" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_8ef90548-5193-47d5-8cfb-42a3d801d62e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_4f3cb5e7-2c39-4d12-ac91-fd178d8f1762" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_8ef90548-5193-47d5-8cfb-42a3d801d62e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_1aa0d0d9-0238-496c-a81c-8aaa56eafdee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_4f3cb5e7-2c39-4d12-ac91-fd178d8f1762" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_1aa0d0d9-0238-496c-a81c-8aaa56eafdee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansReceivableFairValueDisclosure_8f17821d-fde4-4efd-907b-e4aaea8ecbb4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoansReceivableFairValueDisclosure"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_4f3cb5e7-2c39-4d12-ac91-fd178d8f1762" xlink:to="loc_us-gaap_LoansReceivableFairValueDisclosure_8f17821d-fde4-4efd-907b-e4aaea8ecbb4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cass_AccruedInterestReceivableFairValueDisclosure_7e4b85a8-3cf9-48a2-b42d-bfee8566dcf7" xlink:href="cass-20220930.xsd#cass_AccruedInterestReceivableFairValueDisclosure"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_4f3cb5e7-2c39-4d12-ac91-fd178d8f1762" xlink:to="loc_cass_AccruedInterestReceivableFairValueDisclosure_7e4b85a8-3cf9-48a2-b42d-bfee8566dcf7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_44812af4-e272-4342-a112-7283fc9db8c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsFairValueDisclosure_748963c5-fc57-41d3-9e21-aacd3d05e845" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepositsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_44812af4-e272-4342-a112-7283fc9db8c1" xlink:to="loc_us-gaap_DepositsFairValueDisclosure_748963c5-fc57-41d3-9e21-aacd3d05e845" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableFairValueDisclosure_4873b5d9-5b3b-4858-b49f-547761339ad5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_44812af4-e272-4342-a112-7283fc9db8c1" xlink:to="loc_us-gaap_AccountsPayableFairValueDisclosure_4873b5d9-5b3b-4858-b49f-547761339ad5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesFairValueDisclosure_82f7c7ee-4349-4d79-8bd2-b6fa0c15e4d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesFairValueDisclosure"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_44812af4-e272-4342-a112-7283fc9db8c1" xlink:to="loc_us-gaap_AccruedLiabilitiesFairValueDisclosure_82f7c7ee-4349-4d79-8bd2-b6fa0c15e4d6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/RevenuefromContractswithCustomersDetails" xlink:type="simple" xlink:href="cass-20220930.xsd#RevenuefromContractswithCustomersDetails"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/RevenuefromContractswithCustomersDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_38fe7aef-2878-4587-a379-ebca6b53f580" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoninterestIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueNotFromContractWithCustomer_fae398de-ac2c-48b4-812f-553ef638bcfa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueNotFromContractWithCustomer"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_38fe7aef-2878-4587-a379-ebca6b53f580" xlink:to="loc_us-gaap_RevenueNotFromContractWithCustomer_fae398de-ac2c-48b4-812f-553ef638bcfa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_45464af6-e2dc-42f8-a528-423ea7f0260e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_38fe7aef-2878-4587-a379-ebca6b53f580" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_45464af6-e2dc-42f8-a528-423ea7f0260e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/LeasesScheduleofOperatingLeaseMaturityDetails" xlink:type="simple" xlink:href="cass-20220930.xsd#LeasesScheduleofOperatingLeaseMaturityDetails"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/LeasesScheduleofOperatingLeaseMaturityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_a17d9d73-528f-47fb-86d2-34fd235b5916" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_f130ab48-1328-434e-ae65-4f1805805224" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_a17d9d73-528f-47fb-86d2-34fd235b5916" xlink:to="loc_us-gaap_OperatingLeaseLiability_f130ab48-1328-434e-ae65-4f1805805224" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_4ab19500-38bf-4761-be85-a6d614fbdc92" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_a17d9d73-528f-47fb-86d2-34fd235b5916" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_4ab19500-38bf-4761-be85-a6d614fbdc92" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://cassinfo.com/role/LeasesScheduleofOperatingLeaseMaturityDetails_1" xlink:type="simple" xlink:href="cass-20220930.xsd#LeasesScheduleofOperatingLeaseMaturityDetails_1"/>
  <link:calculationLink xlink:role="http://cassinfo.com/role/LeasesScheduleofOperatingLeaseMaturityDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_b132c55d-9c49-468e-8693-0190be89119f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_d46c6d45-1ed5-417e-975b-ab2f3f9aaea9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_b132c55d-9c49-468e-8693-0190be89119f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_d46c6d45-1ed5-417e-975b-ab2f3f9aaea9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_cd0c9419-95bb-49f7-9abe-7ae5dae33004" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_b132c55d-9c49-468e-8693-0190be89119f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_cd0c9419-95bb-49f7-9abe-7ae5dae33004" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_8350b441-dbfa-45be-aafd-8054d6f52ac0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_b132c55d-9c49-468e-8693-0190be89119f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_8350b441-dbfa-45be-aafd-8054d6f52ac0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_8a72cdea-8e17-43b1-95ec-35d98c071b73" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_b132c55d-9c49-468e-8693-0190be89119f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_8a72cdea-8e17-43b1-95ec-35d98c071b73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_f4e568e1-98b1-4193-807e-1e0327286dac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_b132c55d-9c49-468e-8693-0190be89119f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_f4e568e1-98b1-4193-807e-1e0327286dac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cass_LesseeOperatingLeaseLiabilityToBePaidDueAfterYearFour_b6245e59-96d1-4c39-94ae-15a5b11916c7" xlink:href="cass-20220930.xsd#cass_LesseeOperatingLeaseLiabilityToBePaidDueAfterYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_b132c55d-9c49-468e-8693-0190be89119f" xlink:to="loc_cass_LesseeOperatingLeaseLiabilityToBePaidDueAfterYearFour_b6245e59-96d1-4c39-94ae-15a5b11916c7" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
