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	  <link:usedOn>link:calculationLink</link:usedOn>
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	  <link:definition>00000058 - Disclosure - Premises and Equipment (Narrative) (Details)</link:definition>
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	  <link:definition>00000060 - Disclosure - Premises and Equipment (Schedule of Future Minimum Rental Payments) (Details)</link:definition>
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	  <link:definition>00000061 - Disclosure - Acquired Intangible Assets (Narrative) (Details)</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
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	  <link:usedOn>link:calculationLink</link:usedOn>
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	  <link:definition>00000066 - Disclosure - Unused Available Lines of Credit (Details)</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
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	  <link:usedOn>link:calculationLink</link:usedOn>
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	  <link:definition>00000068 - Disclosure - Common Stock and Earnings per Share (Schedule of Calculations of Basic and Diluted Earnings Per Share) (Details)</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
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	  <link:definition>00000069 - Disclosure - Employee Benefit Plans (Narrative) (Details)</link:definition>
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	  <link:definition>00000071 - Disclosure - Employee Benefit Plans (Schedule of Assumptions used to Determine the Projected Benefit Obligation) (Details)</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
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	  <link:definition>00000072 - Disclosure - Employee Benefit Plans (Schedule of Expected Pension Benefit Payments) (Details)</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
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	  <link:definition>00000073 - Disclosure - Employee Benefit Plans (Schedule of Plan's Pension Cost) (Details)</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
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	  <link:usedOn>link:calculationLink</link:usedOn>
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	  <link:usedOn>link:calculationLink</link:usedOn>
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	<link:roleType roleURI="http://cassinfo.com/role/cass-ebpsospcd" id="cass-ebpsospcd">
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    <element id="cass_NoncontributoryProfitSharingProgramMember" name="NoncontributoryProfitSharingProgramMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="cass_DocumentAndEntityInformationAbstract" name="DocumentAndEntityInformationAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="cass_InterestBearingDepositsAbstract" name="InterestBearingDepositsAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="cass_ScheduleOfProjectedBenefitObligationFundedStatusAndAmountsRecognizedTableTextBlock" name="ScheduleOfProjectedBenefitObligationFundedStatusAndAmountsRecognizedTableTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="cass_CreditExposureOfLoanPortfolioAxis" name="CreditExposureOfLoanPortfolioAxis" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" />
    <element id="cass_CreditExposureOfLoanPortfolioDomain" name="CreditExposureOfLoanPortfolioDomain" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="cass_UnamortizedIntangibleAssetAbstract" name="UnamortizedIntangibleAssetAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="cass_WeighteDaverageInterestRateOfTimeDepositsLessThan100000" name="WeighteDaverageInterestRateOfTimeDepositsLessThan100000" nillable="true" xbrli:periodType="instant" type="num:percentItemType" substitutionGroup="xbrli:item" />
    <element id="cass_DefinedBenefitPlanLongTermRateOfReturnOnAssetsExpectedRange" name="DefinedBenefitPlanLongTermRateOfReturnOnAssetsExpectedRange" nillable="true" xbrli:periodType="duration" type="num:percentItemType" substitutionGroup="xbrli:item" />
    <element id="cass_PeriodForExpectedFutureBenefitsPayable" name="PeriodForExpectedFutureBenefitsPayable" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="cass_ProfitSharingExpenseRecognizedInConsolidatedStatementsOfIncome" name="ProfitSharingExpenseRecognizedInConsolidatedStatementsOfIncome" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="cass_DefinedBenefitPlanFairValueOfPlanAssetsAbstract" name="DefinedBenefitPlanFairValueOfPlanAssetsAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="cass_ExpectedLongTermRateReturn" name="ExpectedLongTermRateReturn" nillable="true" xbrli:periodType="duration" type="num:percentItemType" substitutionGroup="xbrli:item" />
    <element id="cass_LongTermRateOfReturnAllocation" name="LongTermRateOfReturnAllocation" nillable="true" xbrli:periodType="duration" type="num:percentItemType" substitutionGroup="xbrli:item" />
    <element id="cass_LongTermRateOfReturnAssumption" name="LongTermRateOfReturnAssumption" nillable="true" xbrli:periodType="duration" type="num:percentItemType" substitutionGroup="xbrli:item" />
    <element id="cass_IncentiveStockOptionsExercised" name="IncentiveStockOptionsExercised" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="cass_IncomeTaxesTable" name="IncomeTaxesTable" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" />
    <element id="cass_IncomeTaxesLineItems" name="IncomeTaxesLineItems" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="cass_PercentageOfOneTimeCharge" name="PercentageOfOneTimeCharge" nillable="true" xbrli:periodType="duration" type="num:percentItemType" substitutionGroup="xbrli:item" />
    <element id="cass_IncomeTaxReconciliationReconcilingItemsAbstract" name="IncomeTaxReconciliationReconcilingItemsAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="cass_DeferredTaxLiabilitiesStockCompensation" name="DeferredTaxLiabilitiesStockCompensation" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="cass_ExpensesAbstract" name="ExpensesAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
</schema>
